Thrombophysiology: The Logical Study of Blood Clots
Venous Blood Clot Life Cycle
Venous blood clots develop after blood flow slows down or stops. The 'compartment syndrome' is a common situation that reduces venous blood flow, which alters metabolism, and decreases the oxygen saturation in the blood. This metabolism without oxygen produces metabolic acid that denatures blood proteins, which causes protein to coagulate with red cells and platelets.
Initially, blood clot debris forms a loose knit purple gel called detritus. This changes over time into a flexible blood clot called a thrombus. These become deep venous thrombosis (DVT). Later, small pieces of DVT break loose from veins inside leg muscles and become venous thromboemboli (VTE) which migrate into the heart. Thrombodextrocardia (VTE in the heart) interfere with blood flow through the valves, which causes palpitations and arrhythmias.
Blood clots inside the right atrium cause fast fluttering sensations with weak fluttering jugular palpitations (pulsus reversus), and blood clots in the right ventricle cause slow flip-flop sensations with skipped heartbeats (pulsus interruptus) as VTE pass through the pulmonary valve.
Thrombodextrocardia causes the tachy-brady rhythm of the sick sinus syndrome, and continuous pulsus interruptus from VTE in the pulmonary valve cause fainting spells, unconscious convulsions, and sudden death syndromes.
After clots leave the right ventricle, they accumulate in the pulmonary artery and pulsate against the esophagus. They squeeze the esophagus and cause nausea, burping, and difficulty talking or swallowing. Burping while sleeping causes gastro-esophageal reflux disease (GERD).
Finally, blood clots move into the lungs and stop in the alveoli, where they are called pulmonary emboli (PE). PE clots made up of detritus gum up the alveoli and interfere with breathing, which causes asthma, panic attacks, narcolepsy, hot flash fevers, and night sweats.
The life cycle of venous blood clots cause a sequence of pathological events
Thrombodextracardia: Venous Thrombo Embolism (VTE) of the Heart
Thrombodextrcardia, VTE of the heart cause the sick sinus syndrome. Moreover, VTE in the pulmonary artery causes burping and burping while sleeping causes gastro esophageal reflux disease (GERD).
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