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  Thrombophysiology: The Logical Study of Blood Clots

Venous Blood Clot Life Cycle

Venous blood clots develop after blood flow slows down or stops. The 'compartment syndrome' is a common situation that reduces venous blood flow, which alters metabolism, and decreases the oxygen saturation in the blood. This metabolism without oxygen produces  metabolic acid that denatures blood proteins, which causes protein to coagulate with red cells and platelets.

Compartment Syndrome

Initially, blood clot debris forms a loose knit purple gel called detritus. This changes over time into a flexible blood clot called a thrombus. These become deep venous thrombosis (DVT). Later, small pieces of DVT break loose from veins inside leg muscles and become venous thromboemboli (VTE) which migrate into the heart. Thrombodextrocardia (VTE in the heart) interfere with blood flow through the valves, which causes palpitations and arrhythmias.

Blood clots inside the right atrium cause fast fluttering sensations with weak fluttering jugular palpitations (pulsus reversus), and blood clots in the right ventricle cause slow flip-flop sensations with skipped heartbeats (pulsus interruptus) as VTE pass through the pulmonary valve.

Thrombodextrocardia causes the tachy-brady rhythm of the sick sinus syndrome, and continuous pulsus interruptus from VTE in the pulmonary valve cause fainting spells, unconscious convulsions, and sudden death syndromes.

After clots leave the right ventricle, they accumulate in the pulmonary artery and pulsate against the esophagus. They squeeze the esophagus and cause nausea, burping, and difficulty talking or swallowing. Burping while sleeping causes gastro-esophageal reflux disease (GERD).

Finally, blood clots move into the lungs and stop in the alveoli, where they are called pulmonary emboli (PE). PE clots made up of detritus gum up the alveoli and interfere with breathing, which causes asthma, panic attacks, narcolepsy, hot flash fevers, and night sweats.

The life cycle of venous blood clots cause a sequence of pathological events 

  1. DVT (deep venous thrombosis) cause muscles inflammation: sore, red, weak, warm, and swollen.
  2. VTE in the tricuspid valve causes fast fluttering light headed jugular palpitations.
  3. VTE in the pulmonary valve causes slow flip flop palpitations and sudden cardiac arrest syndromes.
  4. VTE of the pulmonary artery causes nausea, gagging, burping, and gastro esophageal reflux (GERD).
  5. PE of the alveoli causes panic attacks, asthma, and rare anaphylactic suffocation.
     

Thrombodextracardia: Venous Thrombo Embolism (VTE) of the Heart

Thrombodextrcardia, VTE of the heart cause the sick sinus syndrome. Moreover, VTE in the pulmonary artery causes burping and burping while sleeping causes gastro esophageal reflux disease (GERD).




Sick Sinus Syndrome = Thrombo Tachycardia + Thrombo Bradycardia

Thrombo Tachycardia

Inside the right atrium, VTE cause pulsus reversus, premature atrial contractions, atrial flutter, and atrial fibrillation.

Thrombo Bradycardia

Blood clots inside the right ventricle cause premature ventricular contractions, bigeminy, bradycardia, pulsus interruptus (skipped heartbeats) and continuous skipped beats lead to fainting spells, seizures, and sudden cardiac arrest.


 

Thrombo Ructus causes Gastro Esophageal Reflux Disease

Blood clots accumulate inside the pulmonary artery next to the esophagus and thrombo irritation of the esophagus causes nausea, gagging, burping, and vomiting. Burping while sleeping causes gastro esophageal reflux disease (GERD).


CPR for Thrombocardiac Arrest

 

Cardio Pulmonary Resuscitation (CPR) reanimates an unconscious person with a pulseless electrocardiogram by unclogging the pulmonary valve, which is occluded by a blood clot (VTE in the heart).

 

    • Long blood clots in the pulmonary valve stop blood flow into the lungs and brain
    • Sudden thrombogenic cardiac arrest causes hypoxic acidosis
    • Brain acidosis stops neurotransmission and causes unconsciousness
    • Brain acidosis triggers unconscious anoxic convulsive reflexes
    • Epileptic convulsions perform unconscious CPR
    • Tonic clonic movements by arms and legs pump blood into the  right ventricle
    • Powerful repeating thrusts of blood expel blood clots stuck in the valve
    • CPR performs the Heimlich maneuver on a pulmonary valve obstructed by clots
    • Epileptic CPR restores blood flow into the lungs and brain
    • Blood flow into the lungs and brain reverse acidosis and reanimate victim
    • Elevated CO2 ( hypercapnea) following epilepsy causes postictal narcosis
    • CPR reanimates an unconscious pulseless victim suffering thrombocardiac arrest
    • PR prevents SUDEP, SADS, and sudden unexpected death syndrome
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